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JANUS KINASE 2
Descriptors Found:
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DeCS
Descriptor
English
:
Janus Kinase 2
Descriptor
Spanish
:
Janus Quinasa 2
Descriptor
Portuguese
:
Janus Quinase 2
Synonyms
English
:
JAK-2 Protein Tyrosine Kinase
JAK2 Protein Tyrosine Kinase
JAK 2 Protein Tyrosine Kinase
Tree Number:
D08.811.913.696.620.682.725.124.200
D12.776.476.393.200
D12.776.624.664.700.117
Definition
English
:
A Janus kinase subtype that is involved in signaling from
GROWTH HORMONE
RECEPTORS;
PROLACTIN
RECEPTORS; and a variety of CYTOKINE RECEPTORS such as
ERYTHROPOIETIN
RECEPTORS and
INTERLEUKIN
RECEPTORS. Dysregulation of
Janus kinase 2
due to GENETIC TRANSLOCATIONS have been associated with a variety of
MYELOPROLIFERATIVE DISORDERS.
See Related
English
:
src Homology Domains
History Note
English
:
2007(1992)
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
DF
deficiency
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
SE
secretion
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
52254
Unique Identifier:
D053614
Occurrence in VHL
:
Similar:
DeCS
CID-10
LILACS